Pirfenidone 400 mg (Pirfenex)

What is Pirfenidone 400 mg (Pirfenex)?

Pirfenidone 400 mg, marketed under the brand name Pirfenex, is an oral medication primarily used to treat idiopathic pulmonary fibrosis (IPF). IPF is a chronic and progressive lung disease characterized by scarring of lung tissue, leading to breathing difficulties. Pirfenidone helps slow down the progression of the disease, improving the quality of life for patients.

How Does Pirfenidone Work?

Pirfenidone works by inhibiting the production of substances in the body that cause inflammation and scarring (fibrosis) in the lungs. It modulates the activity of transforming growth factor-beta (TGF-β) and other profibrotic pathways, which are involved in the progression of IPF. By reducing inflammation and fibrosis, it helps maintain lung function for a longer period.

Benefits of Pirfenidone 400 mg

1. Slows Disease Progression: Pirfenidone has been clinically proven to slow the progression of idiopathic pulmonary fibrosis.
2. Improves Breathing: By reducing lung scarring, it helps patients breathe more easily.
3. Enhances Quality of Life: It helps manage symptoms, allowing patients to carry out daily activities with less discomfort.
4. Reduces Inflammation: Its anti-inflammatory properties help minimize further lung damage.

How to Take Pirfenidone 400 mg (Pirfenex)?

1. Dosage: The usual starting dose is gradually increased over two weeks to minimize side effects. The maintenance dose is typically three 400 mg tablets per day, taken with meals.
2. With Food: Always take Pirfenidone with food to reduce the risk of stomach upset.
3. Consistency: Take it at the same time every day to maintain steady drug levels in your body.
4. Missed Dose: If you miss a dose, take it as soon as you remember. However, skip it if it’s almost time for the next dose. Do not double the dose.

Important: Follow your doctor’s instructions carefully and do not stop taking the medication without consulting them.

Who Manufactures Pirfenidone 400 mg (Pirfenex)?

Pirfenex is manufactured by Cipla, a leading pharmaceutical company known for its high-quality and affordable medications. Cipla has a strong reputation for producing effective treatments for chronic and life-threatening conditions.

Is Pirfenidone Safe for Humans?

Pirfenidone is considered safe for humans when prescribed by a healthcare professional and taken as directed. Clinical trials and studies have demonstrated its efficacy and safety for treating IPF. However, it’s essential to monitor for side effects and report any unusual symptoms to your doctor immediately.

Possible Side Effects of Pirfenidone 400 mg

While Pirfenidone is generally well-tolerated, some patients may experience side effects, including:

1. Common Side Effects:
   • Nausea
   • Diarrhea
   • Fatigue
   • Loss of appetite
   • Skin rash (especially with sun exposure)
2. Serious Side Effects:
   • Liver problems (elevated liver enzymes)
   • Photosensitivity reactions
   • Severe allergic reactions

Precautions: Regular liver function tests are recommended during treatment. Avoid excessive sun exposure and use sunscreen to prevent photosensitivity.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or stopping any medication.